Dipeptidyl Peptidase-4 Inhibitor-associated Bullous Pemphigoid: Recurrence with Epitope Spreading
نویسندگان
چکیده
منابع مشابه
Bullous pemphigoid associated with dipeptidyl peptidase‐4 inhibitors: A report of five cases
Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population because of their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here, we report five Japanese cases of BP associated with the ...
متن کاملDipeptidyl Peptidase-4 Inhibitor
In the United States, nearly 13% of adults aged 20 years and older have type 2 diabetes mellitus (T2DM), and its prevalence is still increasing (1,2). Microvascular and macrovascular abnormalities are common in patients with T2DM and are related to the severity and duration of hyperglycemia (3–5). Thus, treatment of hyperglycemia is an important way to prevent or delay diabetic vascular complic...
متن کاملDipeptidyl Peptidase-4 Inhibitors Cause Bullous Pemphigoid in Diabetic Patients: Report of Two Cases
Bullous pemphigoid (BP) is an autoimmune disorder characterized by the production of autoantibodies against two antigens (BPAG1 and 2) and can be induced by drugs (1,2). Recently, the development of BP was reported in diabetic patients treated with dipeptidyl peptidase-4 inhibitors (gliptins) plus metformin (3). However, it remains unknown whether gliptins alone or in combination with metformin...
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A 78-year-old man presented with cutaneous blisters of the limbs and abdominal distension. He had been treated for various diseases, including liver cirrhosis. He had begun receiving sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, for diabetes mellitus three years before the hospitalization. A skin biopsy demonstrated bullous pemphigoid. Ultrasonography (US) revealed multiple liver tum...
متن کاملBullous Pemphigoid in Infancy Showing Epitope-spreading Phenomenon: Recovery with Topical Therapy.
A 6-month-old Japanese boy developed quickly progressing generalised skin lesions. Vaccination was not given in previous 4 weeks. Physical examination revealed extensive annular plaques with blisters and excoriations on entire body (Fig. 1). Laboratory examinations showed increases in leucocytes (32,500/μl; normal, 3,900–9,300/μl), eosinophils (40.5%; normal, 0.2–4.1%) and C-reacting protein (1...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2018
ISSN: 0001-5555
DOI: 10.2340/00015555-3010